Premalignant airway fields in the molecular pathogenesis of lung cancer. Lung cancer risk factors asbestos workplace exposure to asbestos fibers is also a risk factor for lung cancer. Genomic alterations in squamous cell lung cancers have not been. Lung cancer classification pathology immunohistochemistry. Lung cancer is the leading cause of cancer related mortality in the united states. In lung, ezh2 expression is involved in early pathogenesis of scc and correlates with a more aggressive tumor behavior of adenocarcinoma. The pathogenesis of lung cancer is initiated the either the activation of oncogenes or the inactivation of tumor suppressor genes, which leads to uncontrolled replication and growth of the cells. Readytouse cancer presentations presentations are designed to take about 3045 minutes to present. Powerpoint is the worlds most popular presentation software which can let you create professional cell lung cancer powerpoint presentation easily and in no time. This helps you give your presentation on cell lung cancer in a conference, a school lecture, a business proposal, in a webinar and business and professional representations. Powerpoint is the worlds most popular presentation software which can let you create professional epidemiology of lung cancer powerpoint presentation easily and in no time. Lung cancer pathogenesis associated with wood smoke. This overexpression correlates with a poor prognosis, smoking, and the presence of kirsten rat sarcoma kras mutations in nsclc. Lung cancer is the leading cause of cancer deaths in the united states and worldwide in both developing and developed regions.
Mime oncogenes, the first mutation is usually a point mutation affecting a single amino acid in the protein or some other. This helps you give your presentation on epidemiology of lung cancer in a conference, a school lecture, a business proposal, in a webinar and business and professional representations. Extracellular vesicle biology in the pathogenesis of lung. Lung cancer is the leading cause of cancer death, annually resulting in more than one million deaths worldwide.
Other historical data that would suggest lung cancer. Each lung has at least one fissure that divides the lung into smaller lobes. As sccb is histologically indistinguishable from smallcell lung cancer, a shared pathogenesis and cell of origin has been proposed. In the united states, lung cancer is the second most common diagnosed cancer and the leading cause of cancerrelated death.
To determine if epha2 can promote nsclc progression. Epha2 in the early pathogenesis and progression of non. Other historical data that would suggest lung cancer include a history of smoking or exposure to second. Nonsmall cell lung cancer may be further classified into a few histologic subtypes. Differential pathogenesis of lung adenocarcinoma subtypes involving sequence mutations, copy number, chromosomal instability, and methylation. Pdf lung cancers exhibit multiple genetic lesions including mutations. The marked separation of the incidence curves for lung cancer and lung cancer mortality with the 300mg dose during the early period of the trial suggests that canakinumab has an immediate therapeutic effect on established lung tumors, but the lack of baseline scans obfuscates further interpretation. Lung squamous cell carcinoma is a common type of lung cancer, causing approximately 400,000 deaths per year worldwide.
Pathology the term lung cancer is used for tumors arising from the. The role of the ataxia telangiectasia mutated gene in lung. Lung cancer is the major cancer killer worldwide, and 5yr survival is extremely poor. View and download powerpoint presentations on lung pathology ppt. Molecular biology of lung cancer pathogenesis john d.
The right lung is marginally larger because the left lung accommodates the heart by having only 8 segments compared with the right lung, which has 10 segments. This approach can identify candidate oncogenes for evaluation as targets for novel therapeutic. Environmental carcinogens and a gene locus determining susceptibility have been identified. Generally, an ebook can be downloaded in five minutes or less. Lung cancer can be lifethreatening, but doctors can also treat it if they catch it early on. Smallcell carcinoma of the bladder sccb is a rare and aggressive neuroendocrine tumor with a dismal prognosis and limited treatment options.
Lung cancer presentation outline florida cancer data system. Powerpoint is the worlds most popular presentation software which can let you create professional chemoprevention of lung cancer powerpoint presentation easily and in no time. Since 1987, more women have died each year from lung cancer than from breast cancer. Find powerpoint presentations and slides using the power of, find free presentations research about small cell lung cancer ppt. The molecular biology of lung cancer pathogenesis chest. Find powerpoint presentations and slides using the power of, find free. The american cancer society acs 2015 annual report on cancer screening pointed out that lung cancer is the leading cause of death from cancer in both males and females. Government regulations have greatly reduced the use of asbestos in commercial and industrial products in the u. Nov 25, 2016 while lung cancer remains a very challenging cancer to treat, new treatments that capitalize on advances in our understanding of cancer.
Lung cancer facts lung cancer accounts for more deaths than any other cancer in both men and women. View and download powerpoint presentations on small cell lung cancer ppt. Tobacco control programs have led to a significant decline in mortality prognosis of lung cancer still poor, with 5years survival rates of approximately 10% in most countries. Early presentation of lung cancer is characterised by a specific symptomatic pattern. Download figure open in new tab download powerpoint.
American roentgen ray society images of lung cancer pathophysiology. Facts related to lung cancer lung cancer is one of the top ten cancers that affect people in most parts of the world. A vast majority of lung cancer deaths are attributable to cigarette smoking, and curbing the rates of. Over the past 100 years, our understanding of the pathogenesis of lung cancer has advanced impressively.
Mutations in dominant and recessive oncogenes, and the expression of opioid and nicotine receptors in the pathogenesis of lung cancer. In daily practice, however, atypical radiologic features of metastases are often encountered that make distinction of metastases. In 2015, there were 222,000 new lung cancer cases, and 158,000 cases of lungcancerrelated deaths in the united states. Extracellular vesicle biology in the pathogenesis of lung disease. Arsenic high levels in drinking water may increase the. The role of inflammation in the pathogenesis of nonsmall cell lung cancer. This includes cause of the disease, diagnosis, how the. Ppt cancer powerpoint presentation free to download.
Significant advances in lung cancer biology may lead to customised therapy based on targeting specific genes and pathways. There are varying theories on the pathogenesis of cystrelated malignancies, and it is doubtful whether there is a. As sccb is histologically indistinguishable from smallcell lung cancer, a shared pathogenesis. Unresectable nonsmallcell lung cancer treated with. Our new crystalgraphics chart and diagram slides for powerpoint is a collection of over impressively designed datadriven chart and editable diagram s guaranteed to impress any audience. Aug 23, 2018 the pathogenesis of lung cancer is initiated the either the activation of oncogenes or the inactivation of tumor suppressor genes, which leads to uncontrolled replication and growth of the cells. It is likely that a more personalized approach to treatment using biological markers and combinations of therapies will provide better results in the future. I am proud to say i am at almost a month free of bingeing and purging. Dna damage as a molecular link in the pathogenesis of copd. Comprehensive genomic characterization of squamous cell. Lung screening is possible in specific, highrisk categories, but the best way to avoid this serious. Mutations in dominant and recessive oncogenes, and the expression of opioid and nicotine receptors in the pathogenesis of lung cancer in. The left lung is divided in two by a single horizontal fissure that creates an upper and lower lobe. We immunofluorescencestained lung tissue samples obtained from copd patients, asymptomatic smokers and nonsmokers for markers of dsbs.
Lung cancer is the leading cause of cancer death in the united states and around the world. The fiveyear relative survival rate of lung cancer is 16% in canada. To understand lung cancer, it helps to know about the normal structure of the lungs and how they. Pathogenesis of tuberculosis pathogenesis in a previously unexposed, immunocompetent person depends on the development of anti mycobacterial cell mediated immunity,which confers resistance to bacteria and development of hypersensitivity to mycobacterial antigens. Ppt lung cancer pathology powerpoint presentation free to. The pathology of lung cancer has been classified into categories with major clinical implications. Lung cancer accounted for 27% of all death due to cancer. In a sobering testament to its lethality, lung cancer accounts for only 15% of all cancers diagnosed excluding non. Lung cancer is the leading cause of cancer deaths worldwide with lung adenocarcinoma.
Tobacco is considered the most important cause of lung cancer, but other factors could also be involved in its pathogenesis. Perhaps as many as 10 or 20 genetic mutations have occurred by the time lung cancer becomes clinically evident. A free powerpoint ppt presentation displayed as a flash slide show on id. Typical radiologic findings of a pulmonary metastasis include multiple round variablesized nodules and diffuse thickening of interstitium. Epidemiology of lung cancer powerpoint presentation. Visual examination selfexamination clinical physician examination laboratory testing scans mri, cat lung cancer tobacco smoking is the leading cause of various cancers.
Tumor of lung lung cancer being part of the bulimia recovery program brp has been an integral part of my own success. Canakinumab antiinflammatory thrombosis outcomes study lung cancer incidence data. This airway field of injury has been described in smokers with or without lung cancer and is highly relevant for the identification of markers for. Smallcell lung carcinoma sclc, 15% of all lung cancer and nonsmallcell lung carcinoma nsclc, 85% are the two major forms of lung cancer. Lung cancer is the leading cause of cancer deaths in the united states. Although tobacco smoking is the major risk factor accounting for 80% to 90% of all lung cancer diagnoses, there are numerous other risk factors that have been identified as casually associated with lung cancer etiology. Chart and diagram slides for powerpoint beautifully designed chart and diagram s for powerpoint with visually stunning graphics and animation effects. The most frequent and one of the most deadly cancer in men, 8590% of cases can be attributed to tobacco smoking.
The rapid development of targeted therapies has enormously changed the clinical management of lung cancer patients. Pathogenesis of lung cancer is thought to be result of both due. Ppt lung cancer pathology powerpoint presentation free. Lung cancer powerpoint template, backgrounds 08239. Overexpression of the receptor tyrosine kinase epha2 occurs in nonsmall cell lung cancer nsclc and a number of other human cancers. In the united states, lung cancer is the second most common diagnosed cancer and the leading cause of cancer related death. This medical powerpoint template can fit perfectly presentations on lung cancer symptoms, lung cancer diagnosis, lung cancer survival rate, lung cancer stages, lung cancer treatment, lung cancer prognosis, etc. Free download cell lung cancer powerpoint presentation slides.
An increasing number of studies have shown that abnormalities in micrornas play diverse roles in promoting or suppressing cancer. The main signalling pathways that could provide roadmaps for therapy include the following. Treatment of patients with advancedstage nonsmall cell lung cancer with dex resulted in an increased natural killer cell function. Smoking contributes to 80% and 90% of lung cancer deaths in. In other cancers, epha2 has been implicated in migration and metastasis. The high mortality of this disease is in part due to our lacking knowledge of the molecular mechanisms governing lung cancer pathogenesis as well as the late diagnosis of the majority of lung cancers after regional or distant spread of the malignancy. Because of these reasons, at the time of diagnosis, 60% of the time, these tumors have often metastasize to other parts of the body brain, liver. In 2009, over 200,000 new cases of lung cancer were diagnosed and, unfortunately, nearly 160,000 deaths occurred as a result of lung cancer. Major histological types of lung cancer small cell lung cancer sclc, squamous cell. Chemoprevention of lung cancer powerpoint presentation. Pathologists are physicians who are concerned primarily with the study of disease in all its aspects.
Find powerpoint presentations and slides using the power of, find free presentations research about lung pathology ppt. Pdf the molecular biology of lung cancer pathogenesis. The numbers of dsb foci phosphorylated histone 2ax. Enhancer of zeste homolog 2, a potential molecular target of lung cancer, is frequently expressed in nonsmall cell lung carcinoma, and its expression associates with early pathogenesis and correlates with a more aggressive tumor behavior of lung adenocarcinomas. A, smoking induces widespread molecular alterations, such as gene expression changes small red circles, in exposed epithelia throughout the respiratory tract. Several points should lead to the suspicion of lung cancer as the most likely diagnosis, including the irregular borders of the mass arrow, the subacute presentation especially with a mass that is not responding to antibiotics, and the absence of major symptoms. Download free lung cancer professional powerpoint presentation for your presentation. The aim of the present work was to establish an association between wood smoke exposure and lung cancer pathogenesis, and to analyze the effects of wood smoke on p53 and murine double minute 2 mdm2 protein expression. Knowledge of this pattern may help to improve the rate of early diagnosis. Smoking is by far the leading risk factor for lung cancer. These materials are available for use in giving presentations to the public on a variety of cancer topics using the latest information from the american cancer society. In 2015, there were 222,000 new lung cancer cases, and 158,000 cases of lung cancer related deaths in the united states. Oct 12, 2011 tumor of lung lung cancer being part of the bulimia recovery program brp has been an integral part of my own success.
Readytouse cancer presentations american cancer society. Lung cancers are thought to develop over many years. Petct is inferior to mri or ct for the detection of brain metastases. When ezh2 and ttf1 expressions are considered together, they serve as a prognostic marker in patients with surgically resected lung adenocarcinomas. Speaker notes accompanying each presentation explain the information on the slides and will help you answer questions that may come up. Epha2 in the early pathogenesis and progression of nonsmall. The management of patients with nonsmallcell lung cancer nsclc has been transformed in the past 10 years. This helps you give your presentation on chemoprevention of lung cancer in a conference, a school lecture, a business proposal, in a webinar and business and professional representations. Download free medical lung cancer powerpoint presentation. Lung cancer has a poor prognosis, which means incidence closely matches mortality. Arsenic high levels in drinking water may increase the risk of lung cancer, especially in smokers. While lung cancer remains a very challenging cancer to treat, new. With large patient cohorts participating in lung cancer screening programs or undergoing serial crosssectional imaging to monitor other conditions, the prevalence and natural history of lung cancers arising in association with cystic airspaces are becoming more apparent and providing new insights into the pathogenesis of early lung cancer.
In this study, we investigated whether dna doublestrand breaks dsbs contribute to the pathogenesis of chronic obstructive pulmonary disease copd. Primary lung cancer can present as cystic airspace with an associated solid component, and seems to be a relatively common imaging phenotype of early lung cancer. Lung cancer pathogenesis associated with wood smoke exposure. While lung cancer remains a very challenging cancer to treat, new treatments that capitalize on advances in our understanding of cancer. Lung cancer is the leading cause of cancerrelated mortality in the united states.
Differential pathogenesis of lung adenocarcinoma subtypes. Typical carcinoids are different from other types of lung cancers in their presentation at. Lung cancer causes more deaths than the next three common cancers combined colon, breast, prostate. Bronchoscopy bronchial washings, brushings and biopsy bronchial or. Overview of anatomy and pathophysiology of lung cancer.
Early events in the molecular pathogenesis of lung cancer. We demonstrated that 3q 178183 mb amplification is a consistent event in the pathogenesis of squamous lung cancer and is associated with those preinvasive lesions of highest malignant potential. Multistep tumorigenesis, in which tumors develop through a series of progressive pathologic changes preneoplastic or precursor lesions with corresponding genetic and epigenetic aberrations, has been demonstrated in various organs, including the skin, lung, and colon. The incidence of lung cancer was lower in patients treated with canakinumab than in patients receiving placebo. Sequential molecular changes during the multistage pathogenesis of squamous cell lung carcinoma. Lung cancer prevalence, risk factors, prevention, and early. Molecular pathogenesis of earlystage nonsmall cell lung cancer and a proposal for tissue banking to facilitate identification of new biomarkers. Ppt cancer powerpoint presentation free to download id.
1494 365 1299 1155 655 522 256 1077 41 1197 1305 178 1517 785 1043 793 1302 728 618 642 1244 1617 22 1265 215 1640 375 112 1163 782 448 1692 1022 1482 888 436 1457 800 1438 679 497 745 1044 1314